IDA ( Iron Deficiency Anemia )
- 1 ml of RBC == 1 mg of Fe
- Ferritin ↓– storage Iron along with hemosiderin . This is a complex of ferric salt and apoferritin ,protein . differentiates it from ACD,thallasemia,Sideroblastic
- transferrin – transport protein = TIBC ↑
- characterized by hypochromic, microcytic anemia
- MCV ↓ , HCT & HgB ↓
Megaloblastic Anemia
- Macrocytic
- MCV ↑
- B12 and Folic deficiency
- Pernicious Anemia – failure of the gastric mucosa to secrete intrinsic factor
Anemia of Chronic Diseases(ACD)
- Normocytic,normochromic although 20 – 50 % would be microcytic hypochromic
- SI ↓, TIBC normal/↓ ,Ferritin ↑
Sideroblastic Anemia
- Hypochromic, often microcytic mixed with normochromic = dimorphic
- SI ↑, TIBC ↓, % SAT ↑↑
- “ring sideroblasts” in marrow
Blood Loss Anemia
- Acute – normocytic, normochromic
- Chronic – microcytic then hypochromic
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Macrocytic Anemia(Increased MCV)
normochromic base on the film and by the MCHC
- Megaloblastic
- Non-Megaloblastic
Microcytic and Hypochromic Anemias(Decreased MCV and MCH)
MCHC = normal
- IDA
- ACD
- Thallasemia
- Sideroblastic
Normocytic and Normochromic Anemia(Normal MCV)
check Reticulocyte production index and Bone marrow
DAT
hemolytic anemias
SOURCE:
Source:
Henry’s Clinical Diagnosis and Management by Laboratory Methods 21 edition
Chapter 31